Tohoku Univ. Technology : Fermentation of fully-dispersed filamentous fungi mutant : T16-155
Capable of several-fold production of the desired product!
Filamentous fungi (e.g. Aspergillus oryzae) are well-used for production of useful proteins and small molecules in industry. However, it is well-known that hyphal aggregation during the liquid cultivation often prevents from growing with high density, resulting in low productivity. This invention discloses a mutant fungus, in which α-1,3-glucan synthase (AGS) genes plus the genes on galactosaminogalactan (GAG) cluster are deficient. AGS deficient fungi (AGΔ) showed a highly dispersed property [1]. By inducing further deficiency in genes on GAG cluster, the mutant (AGΔ-GAGΔ) shows a fully dispersed state in liquid culture. Further, this phenotype contributes to well aerobic conditions during cultivation, resulting in increasing growth of cells and substance production thereby.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
